We have search the literature to find those protein-bound methionine residues that have been detected, either in vitro or in vivo, as MetO (strong experimental evidence should be provided). Thus, if you wish to know whether your protein of interest has been described to contain MetO sites, you can use this tool. Either introduce the UniProt ID or a word contained in the name of your protein.
| Protein Name | Elongation factor 2 |
|---|---|
| UniProt ID |
Q9ASR1
|
| Gene Name | LOS1 |
| PDB ID | None |
| Sequence |
MVKFTADELRRIMDYKHNIRNMSVIAHVDHGKSTLTDSLVAAAGIIAQEVAGDVRMTDTRADEAERGITIKSTGISLYYEMTDESLKSFTGARDGNEYLINLIDSPGHVDFSSEVTAALRITDGALVVVDCIEGVCVQTETVLRQALGERIRPVLTVNKMDRCFLELQVDGEEAYQTFSRVIENANVIMATYEDPLLGDVQVYPEKGTVAFSAGLHGWAFTLTNFAKMYASKFGVVESKMMERLWGENFFDPATRKWSGKNTGSPTCKRGFVQFCYEPIKQIIATCMNDQKDKLWPMLAKLGVSMKNDEKELMGKPLMKRVMQTWLPASTALLEMMIFHLPSPHTAQRYRVENLYEGPLDDQYANAIRNCDPNGPLMLYVSKMIPASDKGRFFAFGRVFAGKVSTGMKVRIMGPNYIPGEKKDLYTKSVQRTVIWMGKRQETVEDVPCGNTVAMVGLDQFITKNATLTNEKEVDAHPIRAMKFSVSPVVRVAVQCKVASDLPKLVEGLKRLAKSDPMVVCTMEESGEHIVAGAGELHLEICLKDLQDDFMGGAEIIKSDPVVSFRETVCDRSTRTVMSKSPNKHNRLYMEARPMEEGLAEAIDDGRIGPRDDPKIRSKILAEEFGWDKDLAKKIWAFGPETTGPNMVVDMCKGVQYLNEIKDSVVAGFQWASKEGPLAEENMRGICFEVCDVVLHSDAIHRGGGQVIPTARRVIYASQITAKPRLLEPVYMVEIQAPEGALGGIYSVLNQKRGHVFEEMQRPGTPLYNIKAYLPVVESFGFSSQLRAATSGQAFPQCVFDHWEMMSSDPLEPGTQASVLVADIRKRKGLKEAMTPLSEFEDKL
|
| Notes | Either M313, or M318 or both may be sulfoxidized |
| Position | FC | Oxidant | Vivo/Vitro | Tissue | References |
|---|---|---|---|---|---|
| 313 | 1 | high light irradiation | vivo | leaf | |
| 318 | 1 | high light irradiation | vivo | leaf | |
| 481 | 1 | high light irradiation | vivo | leaf | |
| 589 | 1 | 8-Br-cGMP | vivo | suspension culture cells | |
| 594 | 1 | 8-Br-cGMP | vivo | suspension culture cells | |
| 22 | 1 | 8-Br-cGMP | vivo | suspension culture cells | |
| 833 | 1 | 8-Br-cGMP | vivo | suspension culture cells | |
| 682 | 1 | 8-Br-cGMP | vivo | suspension culture cells | |
| 550 | 1 | 8-Br-cGMP | vivo | suspension culture cells |
Data regarding post-translational modifications others than sulfoxidation of methionyl residues were obtained either from PhosPhAt if the protein belongs to Arabidopsis, or from PhosphoSitePlus otherwise.
| PTM Type | Sites |
|---|---|
| Phosphorylation | S838-p S564-p S487-p |
| Acetylation | Any |
| Methylation | Any |
| Ubiquitination | Any |
| Sumoylation | Any |
| OGlcNAc | Any |
| RegPTM | Any |
| Disease | Any |